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Research
In Vivo Optical Imaging for Brains
of Alzheimer's Disease and other organs
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Neurovascular Coupling Dysfunction in Alzheimer's Disease (AD) |
Support by: Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea. (A080945) |
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• Preliminary results: Cerebral blood volume response is augmented in 5-7 months old APPSWE/PS1 ΔE9 ΔAD model mice. |
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• Hypothesis: Neurovascular coupling (NVC) dysfunction underlies the mechanism of Alzheimer's disease progress. Detection of NVC dysfunction might provide early diagnosis of AD. |
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Perivascular Drainage (PVD) and Amyloid Protein Clearance |
Support by: High Risk-High Return Project, KAIST Institute |
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• PVD: Interstitial fluid drainage pathway, along cerebral arteriole walls with its direction against the blood flow. |
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• Hypothesis: PVD provides amyloid protein clearance pathway, and dysfunction of PVD promotes AD progression. |
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• Purpose: To discover methods that can enhance PVD function in aged or AD brains. |
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Effects of Mesenchymal Stem Cell (MSC) on Amyloid Plaques |
Support by: MediPost Co., Ltd |
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• Hypothesis: MSC injection reduces number and volume of amyloid plaque, leading to mitigation of AD symptom. |
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Effects of Phosphodiesterse (PDE) V Inhibitor on Cerebral Blood Vessel |
Support by: Dong-A Pharmaceutical Co., Ltd |
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• Hypothesis: PDE V inhibitor (e.g. udenafil) dilates cerebral blood vessels. |
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• New fluorescence Ca2+ probe for in vitro and in vivo Ca2+ concentration detection. |
• In vivo carotid artery imaging in search of artherosclerosis development mechanism |
• Slow-wave resting state oscillations in AD |
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